Relieving the Wireless Infrastructure: When Opportunistic Networks Meet Guaranteed Delays

Major wireless operators are nowadays facing network capacity issues in striving to meet the growing demands of mobile users. At the same time, 3G-enabled devices increasingly benefit from ad hoc radio connectivity (e.g., Wi-Fi). In this context of hybrid connectivity, we propose Push-and-track, a content dissemination framework that harnesses ad hoc communication opportunities to minimize the load on the wireless infrastructure while guaranteeing tight delivery delays. It achieves this through a control loop that collects user-sent acknowledgements to determine if new copies need to be reinjected into the network through the 3G interface. Push-and-Track includes multiple strategies to determine how many copies of the content should be injected, when, and to whom. The short delay-tolerance of common content, such as news or road traffic updates, make them suitable for such a system. Based on a realistic large-scale vehicular dataset from the city of Bologna composed of more than 10,000 vehicles, we demonstrate that Push-and-Track consistently meets its delivery objectives while reducing the use of the 3G network by over 90%.Comment: Accepted at IEEE WoWMoM 2011 conferenc

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission.

Blocking Plasmodium falciparum transmission to mosquitoes has been designated a strategic objective in the global agenda of malaria elimination. Transmission is ensured by gametocyte-infected erythrocytes (GIE) that sequester in the bone marrow and at maturation are released into peripheral blood from where they are taken up during a mosquito blood meal. Release into the blood circulation is accompanied by an increase in GIE deformability that allows them to pass through the spleen. Here, we used a microsphere matrix to mimic splenic filtration and investigated the role of cAMP-signalling in regulating GIE deformability. We demonstrated that mature GIE deformability is dependent on reduced cAMP-signalling and on increased phosphodiesterase expression in stage V gametocytes, and that parasite cAMP-dependent kinase activity contributes to the stiffness of immature gametocytes. Importantly, pharmacological agents that raise cAMP levels in transmissible stage V gametocytes render them less deformable and hence less likely to circulate through the spleen. Therefore, phosphodiesterase inhibitors that raise cAMP levels in P. falciparum infected erythrocytes, such as sildenafil, represent new candidate drugs to block transmission of malaria parasites

Favoriser l’insertion professionnelle et l’accès à l’emploi

Cherchant à adapter leurs services à l’actualité sociale et aux besoins réels de leur public, de plus en plus de bibliothèques se préoccupent d’offrir des services orientés vers l’insertion professionnelle et la recherche d’emploi. Qu’elle soit universitaire ou publique, la bibliothèque constitue une ressource essentielle de la formation tout au long de la vie, élément primordial à l’adaptation permanente au monde du travail. Cet ouvrage aborde cette nouvelle problématique pour les établissements sous trois angles différents, selon les besoins des publics : travailler, se former, entreprendre. Les conditions d’accueil des publics concernés, l’adaptation de l’offre suivant la dimension de la bibliothèque, la constitution des collections spécialisées dans ce domaine, la qualité des propositions en matière d’autoformation, les atouts des différents partenariats dans le domaine de la recherche d’emploi, tels sont les éléments traités ici pour favoriser le succès de la mise en place et du développement d’une offre propre à élargir avec efficacité les champs d’intervention des bibliothèques aujourd’hui. Coordonné par Georges Perrin, inspecteur général honoraire des bibliothèques, ce volume collectif réunit des professionnels spécialisés dans le domaine éducatif, social et culturel

Utilization of mechanical power and associations with clinical outcomes in brain injured patients: a secondary analysis of the extubation strategies in neuro-intensive care unit patients and associations with outcome (ENIO) trial

Background: There is insufficient evidence to guide ventilatory targets in acute brain injury (ABI). Recent studies have shown associations between mechanical power (MP) and mortality in critical care populations. We aimed to describe MP in ventilated patients with ABI, and evaluate associations between MP and clinical outcomes. Methods: In this preplanned, secondary analysis of a prospective, multi-center, observational cohort study (ENIO, NCT03400904), we included adult patients with ABI (Glasgow Coma Scale ≤ 12 before intubation) who required mechanical ventilation (MV) ≥ 24 h. Using multivariable log binomial regressions, we separately assessed associations between MP on hospital day (HD)1, HD3, HD7 and clinical outcomes: hospital mortality, need for reintubation, tracheostomy placement, and development of acute respiratory distress syndrome (ARDS). Results: We included 1217 patients (mean age 51.2 years [SD 18.1], 66% male, mean body mass index [BMI] 26.3 [SD 5.18]) hospitalized at 62 intensive care units in 18 countries. Hospital mortality was 11% (n = 139), 44% (n = 536) were extubated by HD7 of which 20% (107/536) required reintubation, 28% (n = 340) underwent tracheostomy placement, and 9% (n = 114) developed ARDS. The median MP on HD1, HD3, and HD7 was 11.9 J/min [IQR 9.2-15.1], 13 J/min [IQR 10-17], and 14 J/min [IQR 11-20], respectively. MP was overall higher in patients with ARDS, especially those with higher ARDS severity. After controlling for same-day pressure of arterial oxygen/fraction of inspired oxygen (P/F ratio), BMI, and neurological severity, MP at HD1, HD3, and HD7 was independently associated with hospital mortality, reintubation and tracheostomy placement. The adjusted relative risk (aRR) was greater at higher MP, and strongest for: mortality on HD1 (compared to the HD1 median MP 11.9 J/min, aRR at 17 J/min was 1.22, 95% CI 1.14-1.30) and HD3 (1.38, 95% CI 1.23-1.53), reintubation on HD1 (1.64; 95% CI 1.57-1.72), and tracheostomy on HD7 (1.53; 95%CI 1.18-1.99). MP was associated with the development of moderate-severe ARDS on HD1 (2.07; 95% CI 1.56-2.78) and HD3 (1.76; 95% CI 1.41-2.22). Conclusions: Exposure to high MP during the first week of MV is associated with poor clinical outcomes in ABI, independent of P/F ratio and neurological severity. Potential benefits of optimizing ventilator settings to limit MP warrant further investigation

Event reconstruction for KM3NeT/ORCA using convolutional neural networks

The KM3NeT research infrastructure is currently under construction at two locations in the Mediterranean Sea. The KM3NeT/ORCA water-Cherenkov neutrino detector off the French coast will instrument several megatons of seawater with photosensors. Its main objective is the determination of the neutrino mass ordering. This work aims at demonstrating the general applicability of deep convolutional neural networks to neutrino telescopes, using simulated datasets for the KM3NeT/ORCA detector as an example. To this end, the networks are employed to achieve reconstruction and classification tasks that constitute an alternative to the analysis pipeline presented for KM3NeT/ORCA in the KM3NeT Letter of Intent. They are used to infer event reconstruction estimates for the energy, the direction, and the interaction point of incident neutrinos. The spatial distribution of Cherenkov light generated by charged particles induced in neutrino interactions is classified as shower- or track-like, and the main background processes associated with the detection of atmospheric neutrinos are recognized. Performance comparisons to machine-learning classification and maximum-likelihood reconstruction algorithms previously developed for KM3NeT/ORCA are provided. It is shown that this application of deep convolutional neural networks to simulated datasets for a large-volume neutrino telescope yields competitive reconstruction results and performance improvements with respect to classical approaches

Event reconstruction for KM3NeT/ORCA using convolutional neural networks

The KM3NeT research infrastructure is currently under construction at two locations in the Mediterranean Sea. The KM3NeT/ORCA water-Cherenkov neutrino de tector off the French coast will instrument several megatons of seawater with photosensors. Its main objective is the determination of the neutrino mass ordering. This work aims at demonstrating the general applicability of deep convolutional neural networks to neutrino telescopes, using simulated datasets for the KM3NeT/ORCA detector as an example. To this end, the networks are employed to achieve reconstruction and classification tasks that constitute an alternative to the analysis pipeline presented for KM3NeT/ORCA in the KM3NeT Letter of Intent. They are used to infer event reconstruction estimates for the energy, the direction, and the interaction point of incident neutrinos. The spatial distribution of Cherenkov light generated by charged particles induced in neutrino interactions is classified as shower-or track-like, and the main background processes associated with the detection of atmospheric neutrinos are recognized. Performance comparisons to machine-learning classification and maximum-likelihood reconstruction algorithms previously developed for KM3NeT/ORCA are provided. It is shown that this application of deep convolutional neural networks to simulated datasets for a large-volume neutrino telescope yields competitive reconstruction results and performance improvements with respect to classical approaches

TRY plant trait database – enhanced coverage and open access

Plant traits - the morphological, anatomical, physiological, biochemical and phenological characteristics of plants - determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait‐based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits - almost complete coverage for ‘plant growth form’. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait–environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives

The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases

The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to turn the exponentially growing amount of data into knowledge. Here, we provide an overview of SIB's resources and competence areas, with a strong focus on curated databases and SIB's most popular and widely used resources. In particular, SIB's Bioinformatics resource portal ExPASy features over 150 resources, including UniProtKB/Swiss-Prot, ENZYME, PROSITE, neXtProt, STRING, UniCarbKB, SugarBindDB, SwissRegulon, EPD, arrayMap, Bgee, SWISS-MODEL Repository, OMA, OrthoDB and other databases, which are briefly described in this article

Les questions noires en France : revendications collectives contre perceptions individuelles

Sur fond de revendications sociales et culturelles, l’émergence d’une « conscience noire », mobilisant très activement la mémoire de l’esclavage et les thématiques de discrimination et de visibilité politique et médiatique, s’est produite dans les arènes publiques françaises au début de l’année 2005. Dans une société qui fait de son principe universaliste son crédo, cette apparition pose question. Identifiée par les médias comme étant l’expression d’une « question noire », ces mouvements revendicatifs, émis par un ensemble d’acteurs organisationnels, interrogent sur leur contenu, sur les raisons de leur émission et sur le profil des personnes qui les ont exprimés. Cette recherche sociologique, dont l’objectif est de mettre en évidence la diversité de cette problématique noire, repose sur une enquête de terrain menée sur cinq organisations ayant alimenté cette question et dont l’objectif était d’amener leurs revendications sur le terrain politique. Désignées comme noires, ces organisations, par leur auto-définition et par leurs discours, révèlent l’absence d’unification autour d’une « conscience noire » commune réfutant alors toute idée d’unité de la « question noire ». Les facteurs et les conflits qui opposent notamment les différentes mémoires noires, selon qu’elles concernent les Antillais ou les migrants africains, témoignent de l’existence de plusieurs questions noires. Ces mémoires sont différemment construites et valorisées selon les demandes et les critiques sociales émises par chacun des collectifs. De même, ces derniers, n’aspirant pas à représenter la même population selon qu’ils se revendiquent Antillais, Noirs, Africains ou descendants d’esclaves et de colonisés, combinent et hiérarchisent à leur manière des logiques d’action à partir de leur propre expérience sociale. Deux observations complètent alors cette étude : d’une part le hiatus qui s’est cristallisé entre ces collectivités militantes et les populations noires qu’elles affirment représenter, d’autre part la transformation de l’imaginaire national français qui est interrogé sur sa capacité à intégrer les spécificités propres aux populations noires françaises qui affectent le récit républicain national.In 2005, a black consciousness arise from social and cultural claims reaffirming “slave memory” and discrimination in public sphere and questioning political and media-related visibility of the ones mobilised. This movement, described as the expression of “la question noire”, interrogates the protagonist’s profile and their involvement. This sociological research underlines the diversity of this question. An investigation has been carried out on five organizations with political claims and reveals the non-unification around a common black “consciousness”, disproving the idea of a “black question” unity. The different conceptions of “slave memory”, according to French carribean or Africans migrants concerns, shows several black questions reality based on different social criticism. As a consequence, a diversity of actions exists according to the social experience of these groups. Finally, the study reveals two tendencies. Firstly, the presence of a hiatus between these activist groups and black populations they consider that they represent. Secondly, the transformation of French national imaginary and the reassessment of its capacity to integrate black French populations

Les questions noires en France : revendications collectives contre perceptions individuelles

Sur fond de revendications sociales et culturelles, l’émergence d’une « conscience noire », mobilisant très activement la mémoire de l’esclavage et les thématiques de discrimination et de visibilité politique et médiatique, s’est produite dans les arènes publiques françaises au début de l’année 2005. Dans une société qui fait de son principe universaliste son crédo, cette apparition pose question. Identifiée par les médias comme étant l’expression d’une « question noire », ces mouvements revendicatifs, émis par un ensemble d’acteurs organisationnels, interrogent sur leur contenu, sur les raisons de leur émission et sur le profil des personnes qui les ont exprimés. Cette recherche sociologique, dont l’objectif est de mettre en évidence la diversité de cette problématique noire, repose sur une enquête de terrain menée sur cinq organisations ayant alimenté cette question et dont l’objectif était d’amener leurs revendications sur le terrain politique. Désignées comme noires, ces organisations, par leur auto-définition et par leurs discours, révèlent l’absence d’unification autour d’une « conscience noire » commune réfutant alors toute idée d’unité de la « question noire ». Les facteurs et les conflits qui opposent notamment les différentes mémoires noires, selon qu’elles concernent les Antillais ou les migrants africains, témoignent de l’existence de plusieurs questions noires. Ces mémoires sont différemment construites et valorisées selon les demandes et les critiques sociales émises par chacun des collectifs. De même, ces derniers, n’aspirant pas à représenter la même population selon qu’ils se revendiquent Antillais, Noirs, Africains ou descendants d’esclaves et de colonisés, combinent et hiérarchisent à leur manière des logiques d’action à partir de leur propre expérience sociale. Deux observations complètent alors cette étude : d’une part le hiatus qui s’est cristallisé entre ces collectivités militantes et les populations noires qu’elles affirment représenter, d’autre part la transformation de l’imaginaire national français qui est interrogé sur sa capacité à intégrer les spécificités propres aux populations noires françaises qui affectent le récit républicain national.In 2005, a black consciousness arise from social and cultural claims reaffirming “slave memory” and discrimination in public sphere and questioning political and media-related visibility of the ones mobilised. This movement, described as the expression of “la question noire”, interrogates the protagonist’s profile and their involvement. This sociological research underlines the diversity of this question. An investigation has been carried out on five organizations with political claims and reveals the non-unification around a common black “consciousness”, disproving the idea of a “black question” unity. The different conceptions of “slave memory”, according to French carribean or Africans migrants concerns, shows several black questions reality based on different social criticism. As a consequence, a diversity of actions exists according to the social experience of these groups. Finally, the study reveals two tendencies. Firstly, the presence of a hiatus between these activist groups and black populations they consider that they represent. Secondly, the transformation of French national imaginary and the reassessment of its capacity to integrate black French populations